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butabarbital will minimize the extent or impact of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Impact of coadministering a strong CYP3A4 inducer with fedratinib hasn't been examined.butabarbital will lower the level or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 meta